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![]() ![]() ![]() BOCA demonstrated strong correlation with Montreal Cognitive Assessment (MoCA) ( R = 0.90, p < 0.001). The Cronbach’s alpha was 0.87 implying good internal consistency. Test scores were significantly different between patients and controls ( p < 0.001) suggesting good discriminative ability. BOCA was administered to patients with cognitive impairment ( n = 50) and age- and education-matched controls ( n = 50). BOCA evaluates eight cognitive domains: 1) Memory/Immediate Recall, 2) Combinatorial Language Comprehension/Prefrontal Synthesis, 3) Visuospatial Reasoning/Mental rotation, 4) Executive function/Clock Test, 5) Attention, 6) Mental math, 7) Orientation, and 8) Memory/Delayed Recall. BOCA uses randomly selected non-repeating tasks to minimize practice effects. The goal of this project was to validate BOCA. We developed a self-administered 10-min at-home test intended for longitudinal cognitive monitoring, Boston Cognitive Assessment or BOCA. 2, pp.Longitudinal cognitive testing is essential for developing novel preventive interventions for dementia and Alzheimer’s disease however, the few available tools have significant practice effect and depend on an external evaluator. Journal: Journal of Alzheimer's Disease, vol. Keywords: Alzheimer’s disease, cognitive reserve, functional MRI, imaging, MRI, music Conclusion:These preliminary results suggest that neuroplastic mechanisms may mediate improvements in cognitive functioning associated with exposure to long-known music listening and that these mechanisms may be different in musicians compared to non-musicians. There was also a significant improvement in the memory subdomain of the Montreal Cognitive Assessment. Musician status also significantly modified longitudinal changes in functional and structural brain measures. Post-baseline there was a reduction in brain activity in key nodes of a music-related network, including the bilateral basal ganglia and right inferior frontal gyrus, and declines in fronto-temporal functional connectivity and radial diffusivity of dorsal white matter. Results:Fourteen participants completed the music-based intervention, including 6 musicians and 8 non-musicians. Paired-measures tests evaluated the longitudinal changes in brain structure, function, and cognition associated with the intervention. A cognitive battery was administered, and brain activity was measured before and after intervention. Methods:Participants with early-stage cognitive decline were assigned to three weeks of daily long-known music listening, lasting one hour in duration. Objective:In this pilot study we propose to examine the effect o f repeated long-known music exposure on imaging indices and corresponding changes in cognitive function in patients with early-stage cognitive decline. However, the brain mechanisms underlying improvement in cognitive performance are not yet clear. Ībstract: Background:Repeated exposure to long-known music has been shown to have a beneficial effect on cognitive performance in patients with AD. Michaels Hospital, Room 17044 cc Wing, 30 Bond St., Toronto, Ontario, M5B 1W8, Canada. Fischer, MD, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. | Institute of Medical Sciences, University of Toronto, Toronto, ON, CanadaĬorrespondence to: Corinne E. | University of Toronto, Faculty of Music, Music and Health Science Research Collaboratory, University of Toronto, Toronto, ON, Canada Michael’s Hospital, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Toronto, ON, Canada ![]() a d * | Churchill, Nathan a 1 | Leggieri, Melissa a d | Vuong, Veronica b d | Tau, Michael c | Fornazzari, Luis R. ![]()
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